자연과학대학자연과학대학자연과학대학

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교수 및 연구

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교수 및 연구

교원소개

Chae Un Kim김채운

  • carbonic anhydrase II
  • X-ray crystallography
  • high-pressure cryocooling
  • XFELs
  • active-site water dynamics
  • Structure Elucidation

연구주제

고압·저온 X-ray 기술을 활용한 단백질 구조·동역학 및 물의 상전이 연구

  • 연구분야X-ray Science / Biophysics / Biomedical Science
  • 연구실High Pressure X-ray Science Laboratory

Current Research Interests

  • X-ray Science, Biophysical Science, Biomedical Science: X-ray Diffraction, Protein Structures and Functions, X-ray Imaging of Biological Assemblies.
  • Biophysical study on protein function and dynamics
  • Protein crystals used in X-ray protein crystallography have properties that distinguish them from typical inorganic crystals. An important difference is that protein crystals contain internal water, typically comprising 40 to 60 % of the volume of the crystal. This internal water forms solvent channels inside protein crystals and fills the significant void volume between the folded protein molecules that compose the crystal. We investigate the protein-water interactions inside protein crystals using X-ray diffraction. The results will be helpful to understand the physical origin of protein dynamics in relation to water-protein interactions.

Biographical Sketch

  • Academic Career
  • 2018~Present: Associate Professor, UNIST
  • Assistant Professor (2014 – 2017)
  • Staff Scientist, Cornell High Energy Synchrotron Source (CHESS) (2009-2014)
  • MacCHESS at the Cornell High Energy Synchrotron Source (CHESS), Cornell University Postdoctoral Associate (2008)
  • MacCHESS at the Cornell High Energy Synchrotron Source (CHESS), Cornell University Supervised by Dr. Sol M. Gruner and Dr. Richard A. Cerione
  • Education
  • Ph.D. in Biophysics, Cornell University, Ithaca, NY (2002 – 2008)
  • High Pressure Cryocooling for Macromolecular Crystallography (Dr. Sol M. Gruner, advisor)
  • B.S in Physics, Seoul National University, South Korea (1995 – 1999)
  • Summa Cum Laude (Ranked No.1 in physics department)

Selected Publications

  • "Conformational Flexibility of His200 Enables Catalytic Activity in the T200H Mutant of Carbonic Anhydrase II", Mol. Cells 48(7):100226 (2025).
  • "Fast product release requires active-site water dynamics in carbonic anhydrase", Nature Comm. 16:4404 (2025).
  • "Hidden route of protein damage through oxygen-confined photooxidation", Nature Comm. 15:10873 (2024).
  • "Type-II red phosphorus: wavy packing of twisted pentagonal tubes", Angew. Chem. 62, e202307102 (2023).
  • "Creating tunable mesoporosity by temperature-driven localized crystallite agglomeration", Small 2107006,1-8 (2022).
  • "Elucidating the role of metal ions in carbonic anhydrase catalysis", Nature Comm. 11:4557 (2020).
  • "Direct imaging of structural disordering and heterogeneous dynamics of fullerene molecular liquid", Nature Comm. 10:4395 (2019).
  • "Tracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals", PNAS. USA113, 5257–5262 (2016).
  • "Glass-to-cryogenic-liquid transitions in aqueous solutions suggested by crack healing", PNAS. USA112, 11765-11770 (2015).

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